How Long Does Tretinoin Take To Reduce Wrinkles? by How Long Does Tretinoin Take To Reduce Wrinkles?Does Musely actually work?Musely actually works and here's the proof. Unlike most other beauty products that make lofty claims, tretinoin comes with real proof that it *actually* works. But how long does it take to start working? Fortunately, the answer to that question is it starts working right away! Tretinoin starts working immediately, meaning you’ll start to get the benefits from the medication as soon as you apply it to your skin. However, it usually takes several months before you’ll see a noticeable improvement in your skin after using tretinoin. Several 12 week studies showed clear improvement in skin quality after participants applied topical tretinoin for all 12 weeks. After the studies were complete, researchers saw significant improvement in wrinkles near the lips, smile or laugh lines, and dark spots on the skin. They also saw significant improvement in fine lines around the eyes. Additionally, a 1988 study of topical tretinoin as an anti-aging treatment found that 14 out of 15 people given tretinoin cream “had improvement in photoaging,” compared to none of the people given a non-therapeutic vehicle cream. In general, studies of topical tretinoin for anti-aging usually show results after two to four months of daily use. It's important to understand that tretinoin works best as a long-term treatment. Long-term studies of tretinoin tend to show the most dramatic results, with people experiencing significant reductions in the appearance of fine wrinkling, coarse wrinkling, skin laxity and other signs of photoaging.