Everything You Need To Know About The Estrogen Pill

posted in Guide to HRT/MHT on Dec 18, 2025
Everything You Need To Know About The Estrogen Pill

Menopause can sneak up on you. One day you’re fine, and the next you’re dealing with hot flashes, night sweats, mood changes, and sleep that just won’t cooperate. If this sounds familiar, you’re not imagining it and you don’t have to “just deal with it”.


At Musely, we believe menopause care should feel supportive, approachable, and grounded in real science. Our expert-backed treatments are designed to fit into your life with guidance and support along the way.


What is The Estrogen Pill?


The Estrogen Pill is an FDA-approved, bioidentical oral form of hormone replacement therapy (HRT) designed to help relieve common menopause and perimenopause symptoms like hot flashes, night sweats, and vaginal dryness. Taken once daily, this convenient pill delivers estrogen through the digestive system to help restore the hormone levels.


The Role of Estradiol


Estradiol is the primary estrogen your body naturally produces. As levels decline with age, symptoms can show up in ways no one warned you about. Replenishing estradiol helps address the root cause of menopause symptoms, so you can start feeling steadier, clearer, and more like yourself again. Many women also notice added benefits for skin, hair, and nails.


More Details About The Estrogen Pill


What symptoms does it treat?


The Estrogen Pill, and other forms of HRT, can ease 25 symptoms such as:

Menopause Symptoms

What are the ingredients?


Musely currently offers two strengths of The Estrogen Pill:


  • Estradiol 1mg


  • Estradiol 0.5mg


*Women with a uterus also require progesterone


Prescription is not guaranteed. Our doctors will evaluate your medical history and current condition to determine the best treatment plan. Some ingredients may not be included in your individual prescription.


Expectations:


1. Results can take up to 6-12 weeks.


2. The Estrogen Pill does not cause weight gain, but some women experience temporary mild nausea, bloating, headaches, or breast tenderness initially. These effects are usually mild and improve as hormone levels even out. For information about how to manage side effects, please use eNurse check-ups in the Musely app.


Do’s:


  • Take it exactly as prescribed, once a day.


  • Use progesterone as prescribed if you have a uterus.


  • Swallow the tablet with water and avoid crushing, chewing, or splitting it unless your doctor specifically instructs you to do so.


Don'ts:


  • Do not change your dose without consulting your doctor.


  • Do not take alongside hormonal contraception. 


  • Do not smoke cigarettes, especially if you are 35 or older, without talking to your doctor.


How to Use


To use the medication:


1. Take 1 pill once daily


2. If you're taking progesterone with it, we recommend taking it at nighttime since it can have a sedative effect.


3. Each order includes two bottles (a 60-day supply).



For more Frequently Asked Questions with answers from our team of Board-Certified dermatologists: please visit our DOCTOR FAQ page.