Skincare Ingredients: Use Or Toss? by Musely Editors Skincare Ingredients: Use Or Toss?Retinol and tretinoin are both retinoids which treat signs of anti-aging.Retinol: TossRetinol is a weaker retinoid that is more gentle on the skin, but needs more time to see results.Tretinoin: UseTretinoin a stronger retinoid that is prescription only, allowing you to see significant results in a much shorter amount of time. That's why tretinoin is the key ingredient in The Anti-Aging Night Cream!