Very little changes after 15 weeks of use. Started with the Spot Peel and 7 days later began the Spot Cream. My M Derm started me on the Nurture formula and for the first refill I started the M+ formula (no KA per my M Derm). My M Derm recommended the sandwich method and I’ve been using Vanicream Moisturizing Cream. I know for many people it takes much longer than for others. Any recommendations or advice would be appreciated. I finally ordered the Anti-Aging cream since I lost the Tret when I had to transition to the HQ Free formula, but have only used once.