Easy Way to Get Rid of any Acne, Pimples or Zits Overnight by Sadia Mehnaz Easy Way to Get Rid of any Acne, Pimples or Zits OvernightOkay, so in order to get rid of acne on my face the night before a big event, or just in general, I use toothpaste! Just get a small amount and rub it into the area where there is a lot of acne, or you can just apply a big dollop to a particularly large spot, pimple or zit. Any toothpaste is fine.I hope this helped you guys with any acne issues. Don't worry about it getting all over your pillowcases, as it should dry on your face, so you just need to wash it off the morning after with hopefully, no acne! Another thing that is good for treating acne is to change your pillowcases frequently.