DHEA and Its Impact on Hair Loss by Musely Editors DHEA and Its Impact on Hair LossDehydroepiandrosterone (DHEA) is a hormone produced by the adrenal glands, which serves as a precursor to androgens and estrogens—the sex hormones responsible for regulating various bodily functions. DHEA levels peak in early adulthood and gradually decline as we age, leading some people to use DHEA supplements to offset age-related energy, libido, or muscle mass declines. While DHEA is often touted for its anti-aging benefits, its effect on hair health is more complex, especially for those experiencing hair loss.The Role of DHEA in the BodyDHEA is sometimes referred to as a "parent hormone" because it converts into other key hormones like testosterone and estrogen. These hormones play an essential role in overall health, from maintaining bone density to regulating mood. However, because DHEA can increase levels of testosterone, particularly in women, it may inadvertently influence conditions like hair loss, especially when used in supplement form.Can DHEA Cause Hair Loss?One of the potential side effects of using DHEA supplements is hair loss, especially for individuals genetically predisposed to androgenic alopecia, aka pattern hair loss. Androgenic alopecia is driven by an excess of dihydrotestosterone (DHT), a potent derivative of testosterone. When DHEA supplements increase testosterone levels, they can also raise DHT levels, leading to thinning hair or shedding.Research has shown that higher levels of DHT contribute to the miniaturization of hair follicles, making it difficult for healthy hair to grow. A study published in the Journal of Investigative Dermatology highlighted that androgenic alopecia occurs when DHT binds to androgen receptors in the scalp, shortening the hair growth cycle and leading to follicle shrinkage. Since DHEA converts into testosterone and eventually DHT, it has the potential to exacerbate this process. “Although DHT promotes hair growth in androgen-dependent regions, its action in hairy scalp skin is quite the opposite. Here, evidence shows that one of the causes of hair loss is excess DHT.” (Source: The Hormonal Background of Hair Loss in Non-Scarring Alopecias, 2024)The Link Between DHEA and Hormone Replacement Therapy (HRT)DHEA and hormone replacement therapy (HRT) share a common goal: to restore hormone levels that naturally decline with age. However, there are some critical distinctions between the two.How they’re alike:Both aim to balance hormones: Both DHEA and HRT are used to restore hormone levels, which may alleviate symptoms such as low libido, mood swings, and fatigue.Can influence sex hormones: Both treatments affect estrogen and testosterone, two key hormones involved in skin and hair health.How they differ:HRT typically involves the use of specific hormones (e.g., estrogen and progesterone for women, testosterone for men) to treat menopausal or andropausal symptoms. DHEA, however, serves as a precursor hormone, which the body converts into different hormones like testosterone and estrogen. The effects of DHEA are more indirect and harder to predict.HRT is widely studied, regulated, and approved by the FDA for managing symptoms of menopause and andropause. DHEA supplements, while available over-the-counter in the U.S., are not regulated as strictly and are considered dietary supplements.Because of these differences, DHEA may not be as effective as HRT in treating specific symptoms, and the risk of side effects like hair loss may be more pronounced due to the unpredictable rise in testosterone and DHT levels.What to Do if You're Experiencing Hair Loss While Using DHEAIf you think that DHEA is contributing to hair loss, speak to your healthcare professional. In the meantime, here are some steps you can take:Stop or reduce DHEA supplementation: If DHEA contributes to higher testosterone and DHT levels, pausing or lowering your dose could help reverse the effects. A doctor can guide you through this process.Consider a DHT blocker: Medications like dutasteride or topical treatments like minoxidil work by blocking DHT or stimulating hair growth. These treatments are often prescribed for androgenic alopecia and may help counteract hair loss from increased DHT.Hormone testing: Ask your doctor for blood tests to check hormone levels, including testosterone and DHT. This can help you understand if DHEA is the cause of your hair loss and if other treatments, like HRT, would be more appropriate.Explore alternative therapies: In some cases, switching from DHEA to a more regulated form of hormone replacement therapy (such as bioidentical hormone therapy) may better balance your hormone levels without unwanted side effects like hair thinning.Other Factors to ConsiderWhile DHEA could be a factor to hair loss, it's important to remember that hair loss can result from various causes, including genetics, stress, poor nutrition, and other underlying health conditions like thyroid imbalances. Maintaining a balanced lifestyle with proper diet, stress management, and regular exercise can support overall hair health. Additionally, if you're experiencing other symptoms like fatigue or mood changes, a broader evaluation of your hormone levels may be necessary.DHEA offers potential benefits for those seeking to maintain youthful energy and balance hormone levels, but it’s not without risks. For individuals experiencing hair loss, particularly those predisposed to androgenic alopecia, DHEA supplementation can potentially increase DHT levels, leading to hair thinning. By understanding the relationship between DHEA and hair health, and consulting with a healthcare provider, you can make informed choices about whether to continue using DHEA or explore other options like HRT.If you are concerned about hair loss while using DHEA, a tailored approach involving medical guidance and lifestyle changes can help you preserve both your hair and overall well-being.